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    and as symbionts of other organisms

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    affect the health of our planet

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    Bacterial symbionts of amoebae

    and the evolution of the intracellular lifestyle

  • The human microbiome -

    Our own social network of microbial friends

  • Marine symbioses:

    Listening in on conversations

    between animals and the microbes they can't live without

  • Single cell techniques offer new insights

    into the ecology of microbes

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Dome News

Latest publications

A 12-week intervention with nonivamide, a TRPV1 agonist, prevents a dietary-induced body fat gain and increases peripheral serotonin in moderately overweight subjects

A bolus administration of 0.15 mg nonivamide has previously been demonstrated to reduce energy intake in moderately overweight men. This 12-week intervention investigated whether a daily consumption of nonivamide in a protein-based product formulation promotes a reduction in body weight in healthy overweight subjects, and affects outcome measures associated with mechanisms regulating food intake, e.g. plasma concentrations of an-/orexigenic hormones, energy substrates as well as changes in fecal microbiota .
Nineteen overweight subjects were randomly assigned to either a control (C) or a nonivamide group (NV). Changes in the body composition and plasma concentrations of satiating hormones were determined at fasting and 15, 30, 60, 90 and 120 min after a glucose load. Participants were instructed to consume 0.15 mg nonivamide per day in 450 mL of a milk shake additionally to their habitual diet. After treatment, a group difference in body fat mass change (- 0.61 ± 0.36 % in NV and + 1.36 ± 0.38 % in C), and an increase in postprandial plasma serotonin were demonstrated. Plasma metabolome and fecal microbiome read outs were not affected.
A daily intake of 0.15 mg nonivamide helps to support to maintain a healthy body composition. Nonivamide, a less-pungent capsaicin analog, was studied for its potential as an anti-obesity agent in a 12-week human intervention study. The body composition was determined at the beginning and in the end of intervention. Moreover, plasma concentrations of satiating hormones were measured Participants were instructed to drink the product formulation three times daily. After treatment, a group difference in body fat mass change, and an increase in postprandial plasma serotonin concentrations were determined in the nonivamide group. Thus, we suppose that a daily intake of nonivamide might help to maintain a healthy body composition. This article is protected by copyright. All rights reserved.

Hochkogler CM, Lieder B, Rust P, Berry D, Meier SM, Pignitter M, Riva A, Leitinger A, Bruk A, Wagner S, Hans J, Widder S, Ley JP, Krammer GE, Somoza V
2017 - Mol Nutr Food Res, in press

Microbial nutrient niches in the gut

The composition and function of the mammalian gut microbiota has been the subject of much research in recent years, but the principles underlying the assembly and structure of this complex community remain incompletely understood. Processes that shape the gut microbiota are thought to be mostly niche-driven, with environmental factors such as the composition of available nutrients largely determining whether or not an organism can establish. The concept that the nutrient landscape dictates which organisms can successfully colonize and persist in the gut was first proposed in Rolf Freter's nutrient niche theory. In a situation where nutrients are perfectly mixed and there is balanced microbial growth, Freter postulated that an organism can only survive if it is able to utilize one or a few limiting nutrients more efficiently than its competitors. Recent experimental work indicates, however, that nutrients in the gut vary in space and time. We propose that in such a scenario, Freter's nutrient niche theory must be expanded to account for the co-existence of microorganisms utilizing the same nutrients but in distinct sites or at different times, and that metabolic flexibility and mixed-substrate utilization are common strategies for survival in the face of ever-present nutrient fluctuations.

Pereira FC, Berry D
2017 - Environ. Microbiol., in press

Lecture series

Harnessing Bacteria for Drug Discovery: from Bioprospecting to Synthetic Biology

Sergey Zotchev
Department of Pharmacognosy, University of Vienna
26.01.2017
12:00 h
Hörsaal 2. (UZA I), Althanstrasse 14, A-1090 Vienna

The tale of the rumen microbiome – from interaction with the host to plasmid mediated gene mobility

Itzhak Mizrahi
Ben-Gurion University of the Negev, Israel
22.09.2016
12:00 h
Hörsaal 2. (UZA I)

Importance of chemosymbiotic lucinid bivalves in seagrass community functioning

Matthijs van der Geest
Université de Montpellier
20.01.2016
11:00 h
Seminar room DoME (2.309), UZA 1